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Abbreviations ACSL4: acyl-CoA synthetase long-chain family member 4 AMPK: AMP-activated protein kinase CISD1: CDGSH iron sulfur domain 1 CP: ceruloplasmin DSF: disulfiram GPX4: glutathione peroxidase 4 GSH: glutathione HCC: hepatocellular carcinoma HIF1: hypoxia-inducible factor-1 ICIs: immune checkpoint inhibitors lncRNAs: long noncoding RNAs METTL14: methyltransferase-like 14 MT-1G: metallothionein-1G ncRNAs: noncoding RNAs NRF2: nuclear factor E2-related factor 2 RCD: regulated cell death ROS: reactive oxygen species SCD1: stearoyl-coenzyme A desaturase-1 SLC7A11: solute carrier family 7 member 11 SREBP1: sterol regulatory element-binding protein 1 S1R: Sigma 1 receptor TAZ: transcriptional coactivator with PDZ-binding motif TEAD: transcriptional enhanced associate domain YAP: Yes-associated protein Declarations Funding Hong Kong Scholars Program (Grant No